Dio Brando
JoJo's Bizarre Adventure · 1987
A hundred years of grudge, posed dramatically
A thousand years old and still terrified of dying
Editorial estimates on a 0–100 scale, calibrated against every other character in the index. Not official canon.
Muzan is the origin of every demon in his story, and he can kill any of them with a thought. He hides in plain sight, changing appearance and family whenever it suits him, and his defining trait is not cruelty but cowardice: everything he does, including creating an entire species, is an attempt to solve his own vulnerability to sunlight.
Every demon in the world is an extension of him, and killing them does not touch him.
Sunlight, and the specific flower-based medicine he has spent a millennium failing to perfect.
A thousand years old, capable of killing any of his creations with a thought, and effectively unkillable outside a very specific window of sunlight.
Every demon in the world is an extension of him, which means the threat has been growing continuously for a thousand years.
A thousand-year-old demon king whose defining trait is cowardice, which is a far more interesting choice than pure malice.
JoJo's Bizarre Adventure · 1987
A hundred years of grudge, posed dramatically
The Amazing Spider-Man #300 · 1988
A grudge with teeth, wearing the hero's own costume